Tiny Substances, Huge Duties

Cyclopamine Compound compound PlatformCyclopamine

Cyclopamine is a distinct Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM in TM3Hh12 tissues.

Research limelight: Simply being subjected to cyclopamine motivates pancreatic development in embryonic girls. (Kim SK, et,al. PNAS, 1998, 95: 13036-13041.)

This system can be found in : Bioactive Substance Neighborhood library, All-natural Component Neighborhood local library

TWS119  Substance ConstructionTWS119

TWS119  is actually a GSK-3β inhibitor with IC50 of 30 nM in the cellular-free of charge assay efficient at inducing neuronal differentiation and may be useful to stem cell phone biology.

Examination emphasize: TWS119, a 4,6-disubstituted pyrrolopyrimidine which will result in neurogenesis in murine ESCs. (Ding S, et,al. PNAS, 2003,100(13): 7632-7637. )

The product capabilities in : Bioactive Substance Series

Nicotinamide Chemical compound Construction Nicotinamide

Nicotinamide (Health supplement B3), a h2o-soluble dietary supplement, is unquestionably an energetic element of coenzymes NAD and NADP, plus act as an activator of sirtuins.

Examination stress: nicotinamide greater the make of differentiation of Embryonic Come Cells to pancreatic endocrine tissue (Lumelsky N,et,al.Analysis, 2001, 292(5520): 1389-1394 )

This product includes in : Approved Drug Library, Organic and natural Substance Local library

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Entails 3071 little molecule compounds

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Includes 640 organic and natural substances

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