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MG-132 is undoubtedly an inhibitor of proteasome with IC50 of 100 nM in the mobile phone-totally free assay, and in addition inhibits calpain with IC50 of 1.2 μM.
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Bortezomib (PS-341) is actually a effective 20S proteasome inhibitor with Ki of .6 nM inside a cell-free of charge assay.
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Carfilzomib (PR-171) is undoubtedly an irrevocable proteasome inhibitor with IC50 of 5 nM in ANBL-6 tissue, displayed preferential in vitro inhibitory power up against the ChT-L activity in the β5 subunit, but little or no impact on the PGPH and T-L pursuits.
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