Well-known Supplies in PI3K/Ark/mTOR inhibitor Collection

PI3K

LY294002

CAS No. 154447-36-6

LY294002 is definitely the first unnatural molecule seen to impede PI3Kα/δ/β with IC50 of .5 μM/.57 μM/.97 μM in mobile phone-cost-cost-free assays, respectively a lot more stable in solution than Wortmannin, as well as prevents autophagosome development.

Akt

Perifosine

CAS No. 157716-52-4

Perifosine (KRX-0401) is actually a special Akt inhibitor with IC50 of 4.7 μM in MM.1S cells, concentrates on pleckstrin homology domain address of Akt. Point 3.

mTOR

Perifosine

CAS No. 159351-69-6

Perifosine (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM in the cellular-free assay.

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