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EPZ004777 might be a robust, particular DOT1L inhibitor with IC50 of .4 nM in just a cellular phone-cost-free assay.
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I-BET151 (GSK1210151A) is actually a distinctive discerning Wager inhibitor for BRD2, BRD3 and BRD4 with IC50 of .5 μM, .25 μM, and .79 μM in mobile-charge-free assays, respectively.
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SGI-1027 can be quite a effective and selective inhibitor of DNA methyltransferase (DNMT) with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B, respectively.
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