ROCK inhibitor

Ihibitors

ROCK inhibitor

Y-27632 2HCl Chemical substance FrameworkY-27632 dihydrochlorideGet More Information>>

Y-27632 2HCl can be a discerning ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, shows>200-fold selectivity over other kinases, which include PKC, camp out-reliant proteins kinase, MLCK and PAK.

Associated Goods: Thiazovivin, Fasudil (HA-1077) HCl

GSK-3 inhibitor

CHIR-99021 (CT99021) Chemical substance ConstructionCHIR-99021Find Out More>>

CHIR-99021 (CT99021) HCl is hydrochloride of CHIR-99021, and that is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM capability to separate GSK-3 as well as its nearest homologs Cdc2 and ERK2.

Relevant Merchandise: SB216763 , CHIR-98014

Proteasome Inhibitor

MG-132  Chemical substance ConstructionMilligrams-132Get More Information>>

Milligrams-132 is surely an inhibitor of proteasome with IC50 of 100 nM, and also inhibits calpain with IC50 of 1.2 μM.

Associated Products: Carfilzomib (PR-171) , ONX-0914 (PR-957)

HDAC Inhibitor

Romidepsin (FK228, Depsipeptide) Chemical ConstructionRomidepsin (FK228, Depsipeptide)Get More Information>>

Romidepsin (FK228, depsipeptide) is actually a strong HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.

Associated Merchandise: Entinostat (MS-275) , Trichostatin A (TSA)

Akt Inhibitor

MK-2206 2HCl Chemical substance CompositionMK-2206 2HClGet More Information>>

MK-2206 2HCl is actually a highly discerning inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively no inhibitory routines against 250 other protein kinases seen. Phase 2.

Relevant Products: AZD5363 , GDC-0068

Raf Inhibitor

Vemurafenib  (PLX4032, RG7204) Chemical substance FrameworkVemurafenibLearn More>>

Vemurafenib (PLX4032, RG7204) is really a unique and effective inhibitor of B-RafV600E with IC50 of 31 nM.

Connected Items: Sorafenib Tosylate , PLX-4720

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